A preliminary report on a therapeutic trial with acedapsone in lepromatous leprosy.

Acedapsone in leprosy chemoprophylaxis: field trial in three high-prevalence villages in Micronesia.

Susceptibility of Mycobacterium leprae to dapsone as a determinant of patient response to acedapsone.

In the course of a clinical trial of acedapsone therapy in 17 patients with lepromatous leprosy, the rate of response to therapy was measured by inoculation of mice with Mycobacterium leprae recovered from biopsy specimens of skin lesions obtained before treatment and at intervals of 4, 12, and 24 weeks after institution of treatment. The susceptibility of each isolate of M. leprae to dapsone (...

U.S.-Japan Cooperative Medical Science Program. Workshop on leprosy chemotherapy.

A Workshop on Leprosy Chemotherapy was convened under the auspices of the U.S. Leprosy Panel of the U.S.-Japan Cooperative Medical Science Program of the National Institute of Allergy and Infectious Disease on 26 October 1975 in Bethesda, Maryland. The workshop provided a unique opportunity to bring together participants from other countries as well to discuss three of the most pressing issues ...

De-Novo Presentation of Histoid Leprosy on an Unusual Site

Histoid Leprosy (HL) is a rare variant of Lepromatous Leprosy, occurring in long-standing cases, mostly in a background of acquired drug resistance. Patients usually present with sudden onset multiple nodules and plaques, most often involving the skin and subcutaneous tissue of trunk and lower limbs. Here we report an unusual case of de novo (without any history of prior anti-leprotic therapy) ...

Open trial with clofazimine in the management of recurrent lepra reaction and of sulphone sensitive cases: a preliminary report.

An open trial to assess the value of c10fazimine in the management of cases of lepromatous leprasy with recurrent lepra reaction and those who are sulphone sensitive was commenced in February, 1 9 7 3 . Thalidomide was used as the drug in the contrai subjects. U p to the end of August, 1 9 74 , 6 1 cases have been ad mitted into the study. In the majority of instances the drug had been found to...